Maestría en Estudios Transdisciplinares en Ciencia y Tecnología

Muñoz Toscano Álvaro

• Neurourología funcional y cognitiva: Estudios de investigación básica sobre disfunciones del tracto urinario inferior causadas por afectaciones neurológicas.
• Estudios neuroregenerativos en modelos animales de complicaciones neurológicas: Búsqueda de blancos farmacológicos alternativos que favorezcan la recuperación de funciones neuronales, tanto motoras como sensoriales, después de un daño neurológico. Énfasis en lesión medular.

• 2019 Urethral regions with differential tissular composition may underlie urinary continence and voiding function in female rats. Nancy Mirto-Aguilar, José L. Palacios, Munoz A, Margarita Juárez, Yolanda Cruz. Neurourol Urodyn. Mar;38(3):893-901. DOI: 10.1002/nau.23934
• 2019 Modulatory effects of intravesical P2X2/3R inhibition on the lower urinary tract electromyographic properties and voiding function of female rats with moderate or severe spinal cord injury. Salazar BH, Hoffman KA, Zhang C, Zhang Y, Cruz Y, Boone T, Munoz A*. BJU-Int. Mar;123(3):538-547. doi: 10.1111/bju.14561 (DOI: 10.1111/bju.14561.).
• 2018 Synergistic activities of abdominal muscles are required for efficient micturition in anesthetized female mice. Zhang C, Zhang Y, Cruz Y, Boone T, Munoz A*. Int Neurourol J. Mar; 22(1):9-19 (DOI: 10.5213/inj.1835052.526).
• 2018 Administration of leuprolide acetate, a GnRH agonist, improves urodynamic parameters in ovariectomized rats. Medina-Aguiñaga D, Munoz A, Luna M, Martinez-Moreno CG, Quintanar-Stephano A, Quintanar-Stephano JL. Neurourol Urodyn. June; 37(5): 1574-1582 (DOI: 10.1002/nau.23505).
• 2017 Electrical activity of the bladder is attenuated by intravesical inhibition of P2X2/3 receptors during micturition in female rats. Salazar B, Hoffman K, Zhang C, Kavanagh A, Zhang Y, Boone T, Munoz A*. Int. Neurourol. J.; 21(4): 259-269 (DOI: 10.5213/inj.1734998.499).
• 2017 Neurogenic bladder dysfunction does not correlate with astrocyte and microglia activation produced by graded force in a contusion-induced spinal cord injury. Munoz A* Brain Res Bull. 131:18-24 (DOI: 10.1016/j.brainresbull.2017.02.010).
• 2017. Localized inhibition of P2X7R at the spinal cord injury site improves neurogenic bladder dysfunction by decreasing urothelial P2X3R expression in rats. Munoz A*, et al. Life Sciences. 171: 60-67. (DOI: 10.1016/j.lfs.2016.12.017).
• 2016. Unmasking roles of the peripheral endocannabinoid system associated with bladder overactivity. Munoz A*, BJU Int. 117 (5): 713-714 (DOI: 10.1111/bju.13336).
• 2015 Functional brain interactions during reflexive micturition are absent from spinal cord injured rats with neurogenic bladder. Wong K, Boone TB, Wong S and Munoz A*. Neurourol Urodyn. 34 (5): 469-74. (DOI: 10.1002/nau.22596).
• 2012 Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3 receptors. Munoz A, Somogyi GT, Boone TB, Ford AP, Smith CP. BJU Int. 110: 409-414. (DOI: 10.1111/j.1464-410X.2012.11189.x ).

• Estudios preclínicos para el restablecimiento de la función del tracto urinario inferior posterior a lesiones neurogénicas.
• Wings for Life Spinal Cord Research Foundation: The effect of functional stimulation on synaptic plasticity and integration of iPSC transplants in a rat model of early chronic cervical SCI.
• La fundación Brown. Neuroregenerative Medicine Research Project: Urologic Dysfunction Section.
• Beca para un estudiante de doctorado en el programa académico de la Universidad de Houston y Houston Methodist Research Institute.
• Houston Methodist Research Institute. Fondos para echar a andar laboratorio de Neuro-Regeneration and Bladder Sensory Science Laboratory.
• Allergan Inc. Electromotive intravesical administration of Onabotulinum type A (Botox) in rats with neurogenic bladder.
• Beca postdoctoral de la Juvenile Diabetes Research Foundation International.